| http://purl.uniprot.org/citations/14734805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734805 | http://www.w3.org/2000/01/rdf-schema#comment | "Unrepaired DNA double-strand breaks can lead to apoptosis or tumorigenesis. In mammals double-strand breaks are repaired mainly by nonhomologous end-joining mediated by the DNA-PK complex. The core protein of this complex, DNA-PKcs, is a DNA-dependent serine/threonine kinase that phosphorylates protein targets as well as itself. Although the (auto)phosphorylation activity has been shown to be essential for repair of both random double-strand breaks and induced breaks at the immunoglobulin locus, the corresponding phosphatase has been elusive. In fact, to date, none of the putative phosphatases in DNA double-strand break repair has been identified. Here we show that protein phosphatase 5 interacts with DNA-PKcs and dephosphorylates with surprising specificity at least two functional sites. Cells with either hypo- or hyperphosphorylation of DNA-PKcs at these sites show increased radiation sensitivity."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0307765100"xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0307765100"xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Wabl M."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Wabl M."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Huang B.C."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Huang B.C."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Meek K."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Meek K."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Wechsler T."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Wechsler T."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Chen B.P."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Chen B.P."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Harper R."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Harper R."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Cleaver J.E."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Cleaver J.E."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Morotomi-Yano K."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/author | "Morotomi-Yano K."xsd:string |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14734805 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |