| http://purl.uniprot.org/citations/14736883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14736883 | http://www.w3.org/2000/01/rdf-schema#comment | "The second messenger cAMP mediates potentiation of glucose-stimulated insulin release. Use of inhibitors of cAMP-hydrolyzing phosphodiesterase (PDE) 3 and overexpression of PDE3B in vitro have demonstrated a regulatory role for this enzyme in insulin secretion. In this work, the physiological significance of PDE3B-mediated degradation of cAMP for the regulation of insulin secretion in vivo and glucose homeostasis was investigated in transgenic mice overexpressing PDE3B in pancreatic beta-cells. A 2-fold overexpression of PDE3B protein and activity blunted the insulin response to intravenous glucose, resulting in reduced glucose disposal. The effects were "dose"-dependent because mice overexpressing PDE3B 7-fold failed to increase insulin in response to glucose and hence exhibited pronounced glucose intolerance. Also, the insulin secretory response to intravenous glucagon-like peptide 1 was reduced in vivo. Similarly, islets stimulated in vitro exhibited reduced insulin secretory capacity in response to glucose and glucagon-like peptide 1. Perifusion experiments revealed that the reduction specifically affected the first phase of glucose-stimulated insulin secretion. Furthermore, morphological examinations demonstrated deranged islet cytoarchitecture. In conclusion, these results are consistent with an essential role for PDE3B in cAMP-mediated regulation of insulin release and glucose homeostasis."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m308952200"xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Mulder H."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Ahren B."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Manganiello V.C."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Enerback S."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Sundler F."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Wierup N."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Holst L.S."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Degerman E."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/author | "Harndahl L."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/pages | "15214-15222"xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/title | "Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology."xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14736883 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14736883 |
| http://purl.uniprot.org/citations/14736883 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14736883 |
| http://purl.uniprot.org/uniprot/P14246#attribution-6F4F09F89D6E171279225F7AA713A894 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14736883 |
| http://purl.uniprot.org/uniprot/Q61409#attribution-6F4F09F89D6E171279225F7AA713A894 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14736883 |
| http://purl.uniprot.org/uniprot/#_A2AS86-mappedCitation-14736883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14736883 |
| http://purl.uniprot.org/uniprot/#_E9QLQ3-mappedCitation-14736883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14736883 |
| http://purl.uniprot.org/uniprot/#_E9PXR7-mappedCitation-14736883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14736883 |
| http://purl.uniprot.org/uniprot/#_Q61409-mappedCitation-14736883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14736883 |