| http://purl.uniprot.org/citations/14738308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14738308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14738308 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I collagen in tetrapods is usually a heterotrimeric molecule composed of two alpha1 and one alpha2 chains. In some teleosts, a third alpha chain has been identified by chromatography, suggesting that type I collagen should also exist as an alpha1(I)alpha2(I)alpha3(I) heterotrimer. We prepared, from zebrafish, three distinct cDNAs identified to be those of the collagen alpha1(I), alpha2(I), and alpha3(I) chains. In this study on the evolution of fibrillar collagen alpha chains and their relationships, an exhaustive phylogenetic analysis, using vertebrate fibrillar collagen sequences, showed that each alpha chain constitutes a monophyletic cluster. Results obtained with the newly isolated sequences of the zebrafish showed that the alpha3(I) chain is phylogenetically close to the alpha1(I) chain and support the hypothesis that the alpha3(I) chain arose from a duplication of the alpha1(I) gene. The duplication might occur during the duplication of the actinopterygian genome, soon after the divergence of actinopterygians and sarcopterygians, a hypothesis supported by the demonstration of a syntenic evolution between a set of fibrillar collagen genes and Hox clusters in mammals. An evolutionary scenario is proposed in which phylogenetic relationships of the alpha chains of fibrillar collagens of vertebrates could be related to Hox cluster history."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00239-003-2502-x"xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Garrone R."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Garrone R."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Zylberberg L."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Zylberberg L."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Bonnaud L."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Bonnaud L."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Le Guellec D."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Le Guellec D."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Morvan-Dubois G."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/author | "Morvan-Dubois G."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/name | "J. Mol. Evol."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/name | "J Mol Evol"xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/pages | "501-514"xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/pages | "501-514"xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/title | "Phylogenetic analysis of vertebrate fibrillar collagen locates the position of zebrafish alpha3(I) and suggests an evolutionary link between collagen alpha chains and hox clusters."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/title | "Phylogenetic analysis of vertebrate fibrillar collagen locates the position of zebrafish alpha3(I) and suggests an evolutionary link between collagen alpha chains and hox clusters."xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/14738308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14738308 |