| http://purl.uniprot.org/citations/14739303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14739303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14739303 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptor-3 is critically involved in host defense against viruses through induction of type I interferons (IFNs). Recent studies suggest that a Toll/interleukin-1 receptor domain-containing adapter protein (TRIF) and two protein kinases (TANK-binding kinase-1 (TBK1) and IkappaB kinase (IKK)-epsilon) are critically involved in Toll-like receptor-3-mediated IFN-beta production through activation of IFN regulatory factor (IRF)-3 and IRF-7. In this study, we demonstrate that TRIF interacts with both IRF-7 and IRF-3. In addition to TBK1 and IKKepsilon, our results indicate that IKKbeta can also phosphorylate IRF-3 and activate the IFN-stimulated response element. TRIF-induced IRF-3 and IRF-7 activation was mediated by TBK1 and its downstream kinases IKKbeta and IKKepsilon. TRIF induced NF-kappaB activation through an IKKbeta- and tumor necrosis factor receptor-associated factor-6-dependent (but not TBK1- and IKKepsilon-dependent) pathway. In addition, TRIF also induced apoptosis through a RIP/FADD/caspase-8-dependent and mitochondrion-independent pathway. Furthermore, our results suggest that the TRIF-induced IFN-stimulated response element and NF-kappaB activation and apoptosis pathways are uncoupled and provide a molecular explanation for the divergent effects induced by the adapter protein TRIF."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m311629200"xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m311629200"xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Bin L.H."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Bin L.H."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Xu L.-G."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Xu L.-G."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Shu H.-B."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Shu H.-B."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Han K.J."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/author | "Han K.J."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/pages | "15652-15661"xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/pages | "15652-15661"xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/title | "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."xsd:string |
| http://purl.uniprot.org/citations/14739303 | http://purl.uniprot.org/core/title | "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."xsd:string |