http://purl.uniprot.org/citations/14739855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/14739855 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundSevere burn induces the hepatic acute phase response. In this study, we wondered whether continuous insulin treatment decreases acute phase protein levels in the severely burned.MethodsEighteen children aged 2 to 17 years with burns >40% of total body surface area were randomized to receive either insulin (n=9) or no treatment (n=9) within 72 hours after injury until the wounds were 95% healed. Insulin was given at a continuous rate of > or =1.5 microU/kg/min to maintain euglycemia (serum glucose 100-140 microg/dL). Plasma was examined at days 7, 14, 21, and 28 for acute phase protein levels including C-reactive protein, C3 complement, alpha1-acid glycoprotein, haptoglobin, alpha2-macroglobulin, prealbumin, transferrin, and retinol-binding protein. Statistical analysis was by ANOVA and t test.ResultsWith insulin treatment, alpha1-acid glycoprotein, C3 complement, alpha2-macroglobulin, and haptoglobin levels decreased (P<.05) after a severe burn compared with control, especially at days 21 and 28. Additionally, the hepatic constitutive proteins (prealbumin, transferrin, and retinol-binding protein) were lower in the insulin-treatment group than those of the control group at day 21 (P<.05).ConclusionsContinuous insulin treatment decreases acute phase protein levels after a severe burn. The results suggest insulin downregulation of the hepatic acute phase response to injury."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.surg.2003.08.018"xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/author | "Thomas S.J."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/author | "Wolf S.E."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/author | "Herndon D.N."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/author | "Sanford A.P."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/name | "Surgery"xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/pages | "196-202"xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/title | "Insulin decreases hepatic acute phase protein levels in severely burned children."xsd:string |
http://purl.uniprot.org/citations/14739855 | http://purl.uniprot.org/core/volume | "135"xsd:string |
http://purl.uniprot.org/citations/14739855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14739855 |
http://purl.uniprot.org/citations/14739855 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14739855 |
http://purl.uniprot.org/uniprot/P01308#attribution-B6D24883E90BC4B966FE76D48AC72250 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14739855 |