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http://purl.uniprot.org/citations/14741369http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14741369http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14741369http://www.w3.org/2000/01/rdf-schema#comment"We previously reported the association of a novel Np95/ICBP90-like RING finger protein (NIRF) with a novel PEST-containing nuclear protein (PCNP). NIRF is a nuclear protein with a ubiquitin-like domain, a PHD finger, a YDG/SRA domain, Rb-binding motifs and a RING finger. In this study, we showed that NIRF has auto-ubiquitination activity, the hallmark of a ubiquitin ligase. PCNP was readily ubiquitinated in 293 and COS-7 cells, and NIRF ubiquitinated PCNP in vitro as well as in vivo. Considering that NIRF is implicated in cell cycle regulation, these findings suggest that NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, and may constitute a novel signaling pathway with some relation to cell proliferation."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.org/dc/terms/identifier"doi:10.1016/s0014-5793(03)01495-9"xsd:string
http://purl.uniprot.org/citations/14741369http://purl.org/dc/terms/identifier"doi:10.1016/s0014-5793(03)01495-9"xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Hata H."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Hata H."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Mori T."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Mori T."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Kochi H."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/author"Kochi H."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/pages"209-214"xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/pages"209-214"xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/title"NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/title"NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein."xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/volume"557"xsd:string
http://purl.uniprot.org/citations/14741369http://purl.uniprot.org/core/volume"557"xsd:string
http://purl.uniprot.org/citations/14741369http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14741369
http://purl.uniprot.org/citations/14741369http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14741369