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http://purl.uniprot.org/citations/14742712http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14742712http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14742712http://www.w3.org/2000/01/rdf-schema#comment"Genetic and biochemical evidence has established that a SNARE complex consisting of syntaxin 5 (Sed5)-mYkt6 (Ykt6)-GOS28 (Gos1)-GS15 (Sft1) is required for transport of proteins across the Golgi stack in animals (yeast). We have utilized quantitative immunogold labeling to establish the cis-trans distribution of the v-SNARE GS15 and the t-SNARE subunits GOS28 and syntaxin 5. Whereas the distribution of the t-SNARE is nearly even across the Golgi stack from the cis to the trans side, the v-SNARE GS15 is present in a gradient of increasing concentration toward the trans face of the stack. This contrasts with a second distinct SNARE complex, also required for intra-Golgi transport, consisting of syntaxin 5 (Sed5)-membrin (Bos1)-ERS24 (Sec22)-rBet1 (Bet1), whose v-(rBet1) and t-SNARE subunits (membrin and ERS24), progressively decrease in concentration toward the trans face. Transport within the stack therefore appears to utilize countercurrent gradients of two Golgi SNAREpins and may involve a mechanism akin to homotypic fusion."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.org/dc/terms/identifier"doi:10.1091/mbc.e03-08-0625"xsd:string
http://purl.uniprot.org/citations/14742712http://purl.org/dc/terms/identifier"doi:10.1091/mbc.e03-08-0625"xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Fukasawa M."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Fukasawa M."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Engel T."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Engel T."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Orci L."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Orci L."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Rothman J.E."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Rothman J.E."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Sollner T.H."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Sollner T.H."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Ravazzola M."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Ravazzola M."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Di Liberto M."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Di Liberto M."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Eng W.S."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Eng W.S."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Perrelet A."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Perrelet A."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Varlamov O."xsd:string
http://purl.uniprot.org/citations/14742712http://purl.uniprot.org/core/author"Varlamov O."xsd:string