| http://purl.uniprot.org/citations/14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14744757 | http://www.w3.org/2000/01/rdf-schema#comment | "Aurora-A kinase is frequently overexpressed/activated in human ovarian and breast cancers. A rat mammary tumor model study indicates that alterations of Aurora-A are early events during mammary tumor development (T. M. Goepfert et al., Cancer Res., 62: 4115-4122, 2002), suggesting that Aurora-A plays a pivotal role in transformation. However, the molecular mechanism by which Aurora-A induces ovarian and breast cell transformation remains elusive. Here we show that ectopic expression of Aurora-A induces telomerase activity in human ovarian and breast epithelial cell lines HIOSE118 and MCF-10A. The mRNA and promoter activities of human telomerase reverse transcriptase (hTERT) are stimulated by Aurora-A. Furthermore, we have demonstrated that the c-Myc binding sites of hTERT promoter are required for Aurora-A-induced hTERT promoter activity. Ectopic expression of Aurora-A up-regulates c-Myc. Knockdown of c-Myc by RNA interference attenuates Aurora-A-stimulated hTERT expression and telomerase activity. To our knowledge, these findings demonstrate, for the first time, that Aurora-A induces telomerase activity and hTERT by up-regulation of c-Myc and provides an additional mechanism for the role of Aurora-A in malignant transformation in addition to its cell cycle control."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-03-2907"xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/author | "Cheng J.Q."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/author | "Ou C.C."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/author | "Nicosia S.V."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/author | "Feldman R.I."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/author | "Kruk P.A."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/pages | "463-467"xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/title | "Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/14744757 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14744757 |
| http://purl.uniprot.org/citations/14744757 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14744757 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_B3CJB8-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |
| http://purl.uniprot.org/uniprot/#_B3CJ63-mappedCitation-14744757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14744757 |