| http://purl.uniprot.org/citations/14744933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14744933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14744933 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional coactivator PPAR gamma coactivator 1 alpha (PGC-1alpha) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1alpha in humans have been associated with type II diabetes. PGC-1alpha contains a negative regulatory domain that attenuates its transcriptional activity. This negative regulation is removed by phosphorylation of PGC-1alpha by p38 MAPK, an important kinase downstream of cytokine signaling in muscle and beta-adrenergic signaling in brown fat. We describe here the identification of p160 myb binding protein (p160MBP) as a repressor of PGC-1alpha. The binding and repression of PGC-1alpha by p160MBP is disrupted by p38 MAPK phosphorylation of PGC-1alpha. Adenoviral expression of p160MBP in myoblasts strongly reduces PGC-1alpha's ability to stimulate mitochondrial respiration and the expression of the genes of the electron transport system. This repression does not require removal of PGC-1alpha from chromatin, suggesting that p160MBP is or recruits a direct transcriptional suppressor. Overall, these data indicate that p160MBP is a powerful negative regulator of PGC-1alpha function and provide a molecular mechanism for the activation of PGC-1alpha by p38 MAPK. The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1152204"xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1152204"xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Jaeger S."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Jaeger S."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Fan M."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Fan M."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Puigserver P."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Puigserver P."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Handschin C."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Handschin C."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Rhee J."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "Rhee J."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "St Pierre J."xsd:string |
| http://purl.uniprot.org/citations/14744933 | http://purl.uniprot.org/core/author | "St Pierre J."xsd:string |