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Background

Folate is an important B vitamin that is transported into cells by way of folate-binding proteins and transporters. Folate-binding protein-2 nullizygous (Folbp2(-/-)) mice develop normally; however, we have found them to be more susceptible to the teratogenic effects of arsenate exposure than wild-type control mice.

Methods

In the current study, we wanted to extend our findings and test the hypothesis that Folbp2(-/-) mice are more susceptible to the teratogenic effects of valproic acid (VPA), a commonly used antiepileptic drug that is known to induce neural tube defects (NTDs) in both humans and laboratory animals.

Results

Folbp2(-/-) mice had higher VPA-induced frequencies of embryonic lethality and exencephaly than did the wild-type control mice during folate supplementation and a control diet, respectively. All other differences in response between the two genotypes were short of reaching statistical significance. Folate supplementation of wild-type, but not Folbp2(-/-) dams reduced embryonic lethality of VPA-treated wild-type embryos compared to the folate-deficient diet.

Conclusions

Unlike our previous findings with arsenate, enhanced susceptibility of Folbp2(-/-) mice to in utero VPA exposure was demonstrated in some dietary folate regimens. Thus, our data indicate a relatively frail relationship between Folbp2 and VPA-induced NTDs."xsd:string
http://purl.uniprot.org/citations/14745917http://purl.org/dc/terms/identifier"doi:10.1002/bdra.10128"xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/author"Finnell R.H."xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/author"Spiegelstein O."xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/author"Wicker N.J."xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/author"Merriweather M.Y."xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/name"Birth Defects Res A Clin Mol Teratol"xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/pages"974-978"xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/title"Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice."xsd:string
http://purl.uniprot.org/citations/14745917http://purl.uniprot.org/core/volume"67"xsd:string
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