| http://purl.uniprot.org/citations/14747471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14747471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14747471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14747471 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis C virus (HCV) causes persistent infection in hepatocytes, and this infection is, in turn, strongly associated with the development of hepatocellular carcinoma. To clarify the mechanisms underlying these effects, we established a Cre/loxP conditional expression system for the precisely self-trimmed HCV genome in human liver cells. Passage of hepatocytes expressing replicable full-length HCV (HCR6-Rz) RNA caused up-regulation of anchorage-independent growth after 44 days. In contrast, hepatocytes expressing HCV structural, nonstructural, or all viral proteins showed no significant changes after passage for 44 days. Only cells expressing HCR6-Rz passaged for 44 days displayed acceleration of CDK activity, hyperphosphorylation of Rb, and E2F activation. These results demonstrate that full genome HCV expression up-regulates the CDK-Rb-E2F pathway much more effectively than HCV proteins during passage."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m312822200"xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m312822200"xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m312822200"xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Kohara M."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Kohara M."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Kohara M."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Ohmori H."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Ohmori H."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Ohmori H."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Taira K."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Taira K."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Taira K."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Ohkawa J."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Ohkawa J."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Ohkawa J."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Minatogawa Y."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Minatogawa Y."xsd:string |
| http://purl.uniprot.org/citations/14747471 | http://purl.uniprot.org/core/author | "Minatogawa Y."xsd:string |