| http://purl.uniprot.org/citations/14749395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14749395 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factors MyoD and Myf-5 control myoblast identity and differentiation. MyoD and Myf-5 manifest opposite cell cycle-specific expression patterns. Here, we provide evidence that MyoD plays a pivotal role at the G(2)/M transition by controlling the expression of p21(Waf1/Cip1) (p21), which is believed to regulate cyclin B-Cdc2 kinase activity in G(2). In growing myoblasts, MyoD reaccumulates during G(2) concomitantly with p21 before entry into mitosis; MyoD is phosphorylated on Ser5 and Ser200 by cyclin B-Cdc2, resulting in a decrease of its stability and down-regulation of both MyoD and p21. Inducible expression of a nonphosphorylable MyoD A5/A200 enhances the MyoD interaction with the coactivator P/CAF, thereby stimulating the transcriptional activation of a luciferase reporter gene placed under the control of the p21 promoter. MyoD A5/A200 causes sustained p21 expression, which inhibits cyclin B-Cdc2 kinase activity in G(2) and delays M-phase entry. This G(2) arrest is not observed in p21(-/-) cells. These results show that in cycling cells MyoD functions as a transcriptional activator of p21 and that MyoD phosphorylation is required for G(2)/M transition."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.4.1809-1821.2004"xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Castedo M."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Leibovitch M.P."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Leibovitch S.A."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Sirri V."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Tintignac L.A."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Lecluse Y."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/author | "Metivier D."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/pages | "1809-1821"xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/title | "Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry."xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14749395 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14749395 |
| http://purl.uniprot.org/citations/14749395 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14749395 |
| http://purl.uniprot.org/uniprot/#_A0A087WPR8-mappedCitation-14749395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14749395 |
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| http://purl.uniprot.org/uniprot/#_B2RWS6-mappedCitation-14749395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14749395 |
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