| http://purl.uniprot.org/citations/14751238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14751238 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor binding protein-3 (IGFBP-3) is the most abundant IGFBP in serum and other biological fluids. Apart from its capacity for specific and high-affinity binding to IGFs, it also has so-called "IGF-independent" activities that modulate cell proliferation and survival/apoptosis. However, the molecular elements of the IGFBP-3 signalling pathway remain obscure. In this study, we investigated the possible implication of phosphatidylinositol 3-kinase (PI 3-kinase) activity in MCF-7 breast carcinoma cells. In cells incubated with IGFBP-3, both total and insulin receptor substrate-1 (IRS-1)-associated PI 3-kinase activities were rapidly stimulated, with maximal effects after 3 and 10min of incubation, respectively. IGFBP-3-induced PI 3-kinase activity was unaffected by the state of IRS-1 tyrosine phosphorylation. Since IGFBP-3 failed to stimulate PI 3-kinase activity in MDA-MB 231 breast carcinoma cells, its effects in MCF-7 cells could be considered as cell-type-specific. Pertussis toxin abolished IGFBP-3-stimulation of PI 3-kinase activity, suggesting that this IGFBP-3 signalling pathway depends upon a pertussis toxin-sensitive G protein. Our results provide further evidence that IGFBP-3 directly triggers a specific intracellular signal in MCF-7 cells."xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.01.001"xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/author | "Binoux M."xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/author | "Ricort J.M."xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/pages | "1044-1049"xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/title | "Insulin-like growth factor binding protein-3 stimulates phosphatidylinositol 3-kinase in MCF-7 breast carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/14751238 | http://purl.uniprot.org/core/volume | "314"xsd:string |
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