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| http://purl.uniprot.org/citations/14751759 | http://www.w3.org/2000/01/rdf-schema#comment | "Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.smim.2003.10.009"xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/author | "Takeshita F."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/author | "Klinman D.M."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/author | "Gursel I."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/author | "Gursel M."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/name | "Semin Immunol"xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/pages | "17-22"xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/title | "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9."xsd:string |
| http://purl.uniprot.org/citations/14751759 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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