| http://purl.uniprot.org/citations/14756805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14756805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14756805 | http://www.w3.org/2000/01/rdf-schema#comment | "Ionized calcium binding adaptor molecule 1 (Iba1) is a microglia/macrophage-specific calcium-binding protein. Iba1 has the actin-bundling activity and participates in membrane ruffling and phagocytosis in activated microglia. In order to understand the Iba1-related intracellular signalling pathway in greater detail, we employed a yeast two-hybrid screen to isolate an Iba1-interacting molecule and identified another actin-bundling protein, L-fimbrin. In response to stimulation, L-fimbrin accumulated and co-localized with Iba1 in membrane ruffles induced by M-CSF-stimulation and phagocytic cups formed by IgG-opsonized beads in microglial cell line MG5. L-fimbrin was shown to associate with Iba1 in cell lysate of COS-7 expressing L-fimbrin and Iba1. By using purified proteins, direct binding of Iba1 to L-fimbrin was demonstrated by immunoprecipitation, glutathione S-transferase pull-down assays and ligand overlay assays. The binding of Iba1 was also found to increase the actin-bundling activity of L-fimbrin. These results indicate that Iba1 forms complexes with L-fimbrin in membrane ruffles and phagocytic cups, and suggest that Iba1 co-operates with L-fimbrin in modulating actin reorganization to facilitate cell migration and phagocytosis by microglia."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.02213.x"xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.02213.x"xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Kohsaka S."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Kohsaka S."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Ohsawa K."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/author | "Ohsawa K."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/pages | "844-856"xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/pages | "844-856"xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/title | "Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/title | "Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity."xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/14756805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14756805 |
| http://purl.uniprot.org/citations/14756805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14756805 |