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http://purl.uniprot.org/citations/14763921http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14763921http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Graves' disease (GD) and Hashimoto's thyroiditis (HT) are characterized by lymphocytic infiltrates partly resembling secondary lymphoid follicles in the thyroid. CXCR5 and its ligand CXCL13 regulate compartmentalization of B- and T-cells in secondary lymphoid organs. The aim of the study was to elucidate the role of this chemokine receptor-ligand pair in thyroid autoimmunity.

Methods

Peripheral blood and thyroid-derived lymphocyte subpopulations were examined by flow cytometry for CXCR5. CXCR5 and CXCL13 cDNA were quantified in thyroid tissues by real-time RT-PCR.

Results

We found no differences between the percentages of peripheral blood CXCR5+ T- and B-cells in GD patients (n=10) and healthy controls (n=10). In GD patients, the number of memory CD4+ cells expressing CXCR5 which are functionally characterized as follicular B helper T-cells is higher in thyroid-derived (18+/-3%) compared with peripheral blood T-lymphocytes (8+/-2%). The highest CXCL13 mRNA levels were found in HT (n=2, 86.1+/-1.2 zmol (10(-21) mol) cDNA/PCR) followed by GD tissues (n=16, 9.6+/-3.5). Only low amounts were determined in thyroid autonomy (TA) (n=11) thyroid tissues, irrespective of whether the autonomous nodule (0.5+/-0.1) or the surrounding normal tissue (1.8+/-0.7) had been analyzed. The same differences were found for CXCR5 (HT: 179.1+/-6.8; GD: 17.4+/-10.6; TA(nodule): 0.8+/-0.5; TA(normal): 4.4+/-3.6). In GD, there is a correlation between CXCL13 and CXCR5 mRNA levels and the number of focal lymphocytic infiltrates and germinal centers as well as anti-thyroperoxidase but not anti-TSH receptor autoantibodies.

Conclusions

CXCR5 and CXCL13 play an essential role in maintaining B- and T-cells in lymphocytic infiltrates and ectopic follicles in thyroid tissue from patients affected by autoimmunity."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.org/dc/terms/identifier"doi:10.1530/eje.0.1500225"xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Aust G."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Schutz A."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Anderegg U."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Sittig D."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Lamesch P."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Becherer L."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/author"Schmucking E."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/name"Eur J Endocrinol"xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/pages"225-234"xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/title"The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases."xsd:string
http://purl.uniprot.org/citations/14763921http://purl.uniprot.org/core/volume"150"xsd:string
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