| http://purl.uniprot.org/citations/14764000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764000 | http://www.w3.org/2000/01/rdf-schema#comment | "This study examined whether gonadal steroids are involved in regulating galanin receptor 1 (GalR1) mRNA expression in neurones that contain oestrogen receptor alpha (ERalpha), in three regions of the preoptic area (POA) known to be involved in the control of gonadotropin secretion. Double-labelling immunohistochemistry using an antibody against the ERalpha and in situ hybridization experiments using a 35S-labelled riboprobe specific for GalR1 mRNAs revealed that ERalpha is expressed in a large proportion of GalR1 mRNA-expressing neurones of the POA in the ovariectomized (OVX) female rat. Oestradiol (E2) and oestradiol plus progesterone (E2 + P) treatments of OVX rats significantly decreased the proportion of GalR1 mRNA/ERalpha immunoreactive (ERalpha-IR) neurones in the anteroventral periventricular nucleus (AVPV), medial preoptic nucleus (MPN) and medial preoptic area (MPO). The expression of GalR1 mRNA in ERalpha-IR neurones varied according the hormonal status of the female animals. In the AVPV, during the oestrous cycle, the hybridization signal significantly increased at oestrus. E2 and E2 + P treatments of OVX rats did not induced significant variation of levels of GalR1 mRNAs in ERalpha-IR neurones. In the MPN, E2 treatment of OVX rats resulted in significant increase in GalR1 mRNA expression in ERalpha-IR neurones. Similarly, levels of the GalR1 hybridization signal increased during afternoon of proestrus and oestrus. In the MPO, treatment of OVX rats with E2 + P significantly decreased GalR1 mRNA expression in ERalpha-IR neurones. The expression of GalR1 mRNA did not change during the oestrous cycle in this area. These findings suggest that the hypothalamic action of galanin on gonadotopin-releasing hormone (GnRH) secretion may pass through the specific population of GalR1/ERalpha-IR neurones of the MPN in mediating the oestrogen action on the GnRH system at the moment of the luteinizing hormone surge."xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.0953-8194.2004.01147.x"xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/author | "Mitchell V."xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/author | "Beauvillain J.C."xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/author | "Lecompte F."xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/name | "J Neuroendocrinol"xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/pages | "138-145"xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/title | "Regulation of galanin receptor GalR1 mRNA expression by ovarian steroids in oestrogen receptor alpha-immunoreactive neurones: identification of distinct populations of neurones in the preoptic area."xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/14764000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14764000 |
| http://purl.uniprot.org/citations/14764000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14764000 |
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| http://purl.uniprot.org/uniprot/#_Q62805-mappedCitation-14764000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764000 |
| http://purl.uniprot.org/uniprot/#_Q62828-mappedCitation-14764000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764000 |
| http://purl.uniprot.org/uniprot/A6K5J0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14764000 |
| http://purl.uniprot.org/uniprot/Q62805 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14764000 |
| http://purl.uniprot.org/uniprot/Q62828 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14764000 |