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| http://purl.uniprot.org/citations/14764669 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-21 is a recently identified cytokine that stimulates mouse NK cell effector functions in vitro. In this study we demonstrate that IL-21 achieves its stimulatory effect by inducing the development of mature NK cells into a large granular lymphocyte phenotype with heightened effector function. IL-21 treatment results in increased cell size and granularity and a corresponding decrease in cell viability and proliferative potential. These cells up-regulate the expression of the inhibitory CD94-NKG2A receptor complex and the activation markers CD154 and killer cell, lectin-like-receptor G1. Surprisingly, IL-21 treatment also results in down-regulation of the pan-NK marker, NK1.1. Coinciding with these cellular changes IL-21 enhances cytolytic capacity across a spectrum of target sensitivities and induces IL-10 and IFN-gamma production. In vivo treatment with IL-21 results in a very similar activation and phenotypic maturation of NK cells as well as a potent increase in NK cell-mediated anti-tumor immunity that is perforin dependent. These developmental changes suggested that IL-21 functions to induce the terminal differentiation of mouse NK cells, resulting in heightened NK cell-mediated cytotoxicity and immune surveillance."xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.4.2048"xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/author | "Hayakawa Y."xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/author | "Brady J."xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/author | "Nutt S.L."xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/pages | "2048-2058"xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/title | "IL-21 induces the functional maturation of murine NK cells."xsd:string |
| http://purl.uniprot.org/citations/14764669 | http://purl.uniprot.org/core/volume | "172"xsd:string |
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