| http://purl.uniprot.org/citations/14764690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764690 | http://www.w3.org/2000/01/rdf-schema#comment | "The recently discovered cytokine IL-27 belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. Although binding of IL-27 to the cytokine receptor WSX-1 was demonstrated, this interaction proved insufficient to mediate cellular effects. Hence, IL-27 was believed to form a heteromeric signaling receptor complex with WSX-1 and another, yet to be identified, cytokine receptor subunit. In this study, we describe that WSX-1 together with gp130 constitutes a functional signal-transducing receptor for IL-27. We show that neither of the two subunits itself is sufficient to mediate IL-27-induced signal transduction, but that the combination of both is required for this event. Expression analysis of WSX-1 and gp130 by quantitative PCR suggests that IL-27 might have a variety of cellular targets besides naive CD4(+) T cells: we demonstrate gene induction of a subset of inflammatory cytokines in primary human mast cells and monocytes in response to IL-27 stimulation. Thus, IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.4.2225"xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.4.2225"xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Rosales R."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Rosales R."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "McClanahan T.K."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "McClanahan T.K."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Vaisberg E."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Vaisberg E."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Phillips J.H."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Phillips J.H."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Pflanz S."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Pflanz S."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Kastelein R.A."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Kastelein R.A."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "de Waal Malefyt R."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "de Waal Malefyt R."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Mattson J."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Mattson J."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Hibbert L."xsd:string |
| http://purl.uniprot.org/citations/14764690 | http://purl.uniprot.org/core/author | "Hibbert L."xsd:string |