| http://purl.uniprot.org/citations/14764715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764715 | http://www.w3.org/2000/01/rdf-schema#comment | "Basophil contribution to the IL-4 pool in filarial infections was assessed using PBMC from 20 patients with active filarial infections and from 9 uninfected subjects. Patient basophils released histamine in response to Brugia malayi Ag (BmAg). They also released IL-4 within 2 h after exposure to BmAg, as assessed by intracellular cytokine flow cytometry. This IL-4 induction was Ag specific, as IL-4 was not detected in BmAg-exposed basophils obtained from uninfected subjects. Although there were, on average, 64 times more CD4(+) T cells than basophils in the peripheral circulation of filaria-infected patients, the absolute numbers of basophils and CD4(+) T cells producing IL-4 per 100000 PBMC were equivalent (geometric mean: 16 IL-4-producing basophils/100000 PBMC vs 22 IL-4-producing CD4(+) T cells/100000 PBMC). Basophils also released IL-4 in response to both low and high concentrations of BmAg, whereas CD4(+) T cells released IL-4 only after incubation with a high concentration of BmAg, raising the possibility that basophils, due to their lower threshold for activation, may actually release IL-4 more frequently than CD4(+) T cells in vivo. Furthermore, IL-4 production in vitro by Ag-stimulated purified basophils or CD4(+) T cells provided evidence that basophils release greater quantities of IL-4 per cell than CD4(+) T cells in response to BmAg. These results suggest that, when Ag-specific IgE is present in a filaria-infected individual, basophils function to amplify the ongoing Th2 response by releasing IL-4 in greater amounts and possibly more frequently than CD4(+) T cells in response to filarial Ag."xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.4.2439"xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/author | "Nutman T.B."xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/author | "Kubofcik J."xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/author | "Taylor R.T."xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/author | "Mitre E."xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/pages | "2439-2445"xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/title | "Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections."xsd:string |
| http://purl.uniprot.org/citations/14764715 | http://purl.uniprot.org/core/volume | "172"xsd:string |
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