| http://purl.uniprot.org/citations/14764729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764729 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of murine macrophages with LPS results in the coordinated activation of a set of proinflammatory cytokines and costimulatory molecules, including TNF-alpha, IL-6, IL-1, IL-8, IL-12, and CD80. Macrophage LPS-induced synthesis of IL-12 is inhibited following FcgammaR ligation; TNF-alpha secretion is unchanged. We report that microtubule-associated serine/threonine kinase-205 kDa (MAST205) is required for LPS-induced IL-12 synthesis. RNA interference-mediated suppression of MAST205 results in the inhibition of LPS-stimulated IL-12 promoter activity and IL-12 secretion, from both J774 cells and bone marrow-derived macrophages. Similarly, dominant-negative MAST205 mutants inhibit LPS-stimulated IL-12 synthesis and NF-kappaB activation, but do not affect IL-1 or TNF-alpha signaling. Finally, macrophage FcgammaR ligation regulates MAST205 by inducing the rapid ubiquitination and proteasomal degradation of the protein."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.4.2559"xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.4.2559"xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Plevy S.E."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Plevy S.E."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Walden P.D."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Walden P.D."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Prestwich G.D."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Prestwich G.D."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Unkeless J.C."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Unkeless J.C."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Sassaroli M."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/author | "Sassaroli M."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/14764729 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |