| http://purl.uniprot.org/citations/14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764822 | http://www.w3.org/2000/01/rdf-schema#comment | "Mounting evidence exists for a role of the CRH system in energy balance, including a direct influence on human adipocytes, the regulation of adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity, and cortisol formation. We characterized the expression of CRH receptors 1 and 2 and CRH-like peptides stresscopin and urocortin in human adipose tissue in comparison with other peripheral tissues, adrenal, and heart. The effect of CRH on CRH receptor and CRH-like peptide expression was analyzed in isolated human adipocytes using quantitative TaqMan PCR. CRH receptors were detectable in fat tissue at mRNA and protein levels. CRH-R2 expression in fat was comparable with its expression in the heart, the organ with the highest CRH-R2 expression known. CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2. Adipose tissue also expressed urocortin and stresscopin, the predominant ligands of peripheral CRH-R2. CRH down-regulated CRH-R1 and CRH-R2 mRNA expression in isolated adipocytes. These data, together with the recently published observation that CRH regulates adipocyte metabolism by down-regulating 11 beta-hydroxysteroid dehydrogenase, indicate that a CRH system exists within human adipose tissue. This system could be implicated in energy homeostasis and in mediating the anorexic effects of CRH at adipose level."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2003-031299"xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Scherbaum W.A."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Bornstein S.R."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Willenberg H.S."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Schulte K.M."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Ehrhart-Bornstein M."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Seres J."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/author | "Seres P."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/pages | "965-970"xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/title | "Corticotropin-releasing hormone system in human adipose tissue."xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/14764822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14764822 |
| http://purl.uniprot.org/citations/14764822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14764822 |
| http://purl.uniprot.org/uniprot/#_A0A090N7T4-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_A0A1U6XTF7-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_B3SXS2-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_B3SXS9-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_B3TIK8-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_G3CIS4-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_K9J956-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |
| http://purl.uniprot.org/uniprot/#_P55089-mappedCitation-14764822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14764822 |