| http://purl.uniprot.org/citations/14767517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14767517 | http://www.w3.org/2000/01/rdf-schema#comment | "The chromosome region 11q is frequently deleted in colorectal cancers. The PPP2R1B tumor suppressor gene, encoding the beta isoform of the A subunit of serine/threonine-specific protein phosphatase 2A (PP2A-Abeta), located at 11q22-23, is inactivated in patients with cancer. The present study investigated whether or not PP2A-Abeta is altered in colorectal cancers. We searched for alterations of the PPP2R1B gene and interactions between PP2A-Abeta and PP2A-C proteins in 50 surgically resected colorectal cancer tissues. Missense mutations and homozygous deletions of the PPP2R1B gene were found in 4 of 50 patients (8%) and in 1 of 50 patients, respectively, with colorectal cancers. Deletions and/or point mutations within 412-601 amino acid sequences (binding regions of PP2A-C protein) of the PPP2R1B gene derived from colorectal cancer tissues inhibited co-immunoprecipitation of PP2A-Abeta and PP2A-C proteins. These finding suggested that the PPP2R1B gene functions as a tumor suppressor gene and acts as a molecular switch that becomes active in response to specific up-stream signals. Upon activation, the gene alters the activities of specific downstream target proteins for the cell cycle regulations and/or metabolism in some colorectal cancers."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/author | "Katayama K."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/author | "Yamaguchi A."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/author | "Tamaki M."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/author | "Goi T."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/author | "Hirono Y."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/pages | "655-659"xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/title | "PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers."xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/14767517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14767517 |
| http://purl.uniprot.org/citations/14767517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14767517 |
| http://purl.uniprot.org/uniprot/#_B7Z1G3-mappedCitation-14767517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767517 |
| http://purl.uniprot.org/uniprot/#_A8K8B0-mappedCitation-14767517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767517 |
| http://purl.uniprot.org/uniprot/#_P30154-mappedCitation-14767517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767517 |
| http://purl.uniprot.org/uniprot/B7Z1G3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14767517 |
| http://purl.uniprot.org/uniprot/P30154 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14767517 |
| http://purl.uniprot.org/uniprot/A8K8B0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14767517 |