| http://purl.uniprot.org/citations/14767995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14767995 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic ischemia/reperfusion (I/R) injury associated with liver transplantation and hepatic resection is characterized by hepatocellular damage and a deleterious inflammatory response. In this study, we examined whether receptor for advanced glycation end product (RAGE) activation is linked to mechanisms accentuating inflammation on I/R in a murine model of total hepatic ischemia. Animals treated with soluble RAGE (sRAGE), the extracellular ligand-binding domain of RAGE, displayed increased survival after total hepatic I/R compared with vehicle treatment. TUNEL assay and histologic analysis revealed that blockade of RAGE was highly protective against hepatocellular death and necrosis on I/R; in parallel, proliferating cell nuclear antigen was enhanced in livers of mice treated with sRAGE. Rapid activation of p38, p44/42, stress-activated protein kinase and c-Jun N-terminal kinase mitogen-activated protein kinases, signal transducer and activator of transcription-3, and nuclear translocation of activator protein-1 was evident at early times on I/R. In the remnants of sRAGE-treated livers, however, activation of each of these signaling and transcription factor pathways was strikingly decreased. sRAGE-treated remnants displayed enhanced activation of nuclear factor kappaB, in parallel with increased transcripts for the proregenerative cytokine, tumor necrosis factor-alpha. In conclusion, these data suggest that RAGE modulates hepatic I/R injury, at least in part by activation of key signaling pathways linked to proinflammatory and cell death-promoting responses. We propose that blockade of this pathway may represent a novel strategy to attenuate injury in hepatic I/R and to facilitate regeneration."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.org/dc/terms/identifier | "doi:10.1002/hep.20045"xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Zeng S."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Qu W."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Schmidt A.M."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Goldstein M."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Dun H."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Ekong U."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Emond J.C."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Feirt N."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Guarrera J."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/author | "Ippagunta N."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/name | "Hepatology"xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/pages | "422-432"xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/title | "Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice."xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/14767995 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14767995 |
| http://purl.uniprot.org/citations/14767995 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14767995 |
| http://purl.uniprot.org/uniprot/#_F1ABR7-mappedCitation-14767995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767995 |
| http://purl.uniprot.org/uniprot/#_F1ABR8-mappedCitation-14767995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767995 |
| http://purl.uniprot.org/uniprot/#_F1ABR9-mappedCitation-14767995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767995 |
| http://purl.uniprot.org/uniprot/#_F1ABS0-mappedCitation-14767995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14767995 |