http://purl.uniprot.org/citations/14769517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/14769517 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate the association between the HLA-DRB1 alleles sharing the epitope (Q/R)(K/R)RAA and rheumatoid arthritis (RA) in a large sample of Italian patients (N = 264) recruited from a single centre over the last 5 years.MethodsPatients' classification according to the ACR criteria. DNA typing of HLA-DRB1 alleles by conventional polymerase chain reaction sequence specific oligonucleotide probing techniques.ResultsLow-resolution DRB1 "generic" typing showed a significantly higher frequency of DR4+ RA patients as compared to normal controls. Both DR1 and DR10 specificities were over-represented in our patients, but neither reached the statistically significant P level of 0.05 after Bonferroni's correction. However, direct search of Q(K/R)RAA epitopes, which are present in most DR4+ and DRl+ samples, demonstrated that these motifs were found at increased frequencies in RA patients. Stratification according to gender did not show differences in the proportion of disease-associated HLA alleles.ConclusionsOur study confirms the association of HLA-DR4, and -DR1 alleles, and more generally speaking of the shared epitopes Q(K/R)RAA, with disease susceptibility in Italian patients."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1297-319x(03)00099-x"xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/author | "Porfirio B."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/author | "Rombola G."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/author | "Beneforti E."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/author | "Bianucci G."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/author | "Bongi S.M."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/author | "Palasciano A."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/name | "Joint Bone Spine"xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/pages | "24-28"xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/title | "Shared-epitope HLA-DRB1 alleles and sex ratio in Italian patients with rheumatoid arthritis."xsd:string |
http://purl.uniprot.org/citations/14769517 | http://purl.uniprot.org/core/volume | "71"xsd:string |
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