| http://purl.uniprot.org/citations/14769789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14769789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14769789 | http://www.w3.org/2000/01/rdf-schema#comment | "Modulation of mRNA stability by regulatory cis-acting AU-rich elements (AREs) and ARE-binding proteins is an important posttranscriptional mechanism of gene expression control. We previously demonstrated that the 3'-untranslated region of BCL-2 mRNA contains an ARE that accounts for rapid BCL-2 down-regulation in response to apoptotic stimuli. We also demonstrated that the BCL-2 ARE core interacts with a number of ARE-binding proteins, one of which is AU-rich factor 1/heterogeneous nuclear ribonucleoprotein D, known for its interaction with mRNA elements of others genes. In an attempt to search for other BCL-2 mRNA-binding proteins, we used the yeast RNA three-hybrid system assay and identified a novel human protein that interacts with BCL-2 ARE. We refer to it as TINO. The predicted protein sequence of TINO reveals two amino-terminal heterogeneous nuclear ribonucleoprotein K homology motifs for nucleic acid binding and a carboxyl-terminal RING domain, endowed with a putative E3 ubiquitin-protein ligase activity. In addition the novel protein is evolutionarily conserved; the two following orthologous proteins have been identified with protein-protein BLAST: posterior end mark-3 (PEM-3) of Ciona savignyi and muscle excess protein-3 (MEX-3) of Caenorhabditis elegans. Upon binding, TINO destabilizes a chimeric reporter construct containing the BCL-2 ARE sequence, revealing a negative regulatory action on BCL-2 gene expression at the posttranscriptional level."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m314071200"xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m314071200"xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M314071200"xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Jacquier A."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Jacquier A."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Brewer G."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Brewer G."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Witort E."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Witort E."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Capaccioli S."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Capaccioli S."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Donnini M."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Donnini M."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Lapucci A."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Lapucci A."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Nicolin A."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Nicolin A."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Papucci L."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Papucci L."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Schiavone N."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/author | "Schiavone N."xsd:string |
| http://purl.uniprot.org/citations/14769789 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |