| http://purl.uniprot.org/citations/14769925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14769925 | http://www.w3.org/2000/01/rdf-schema#comment | "TIA-1 and TTP are AU-rich element-binding proteins that prevent the pathological overexpression of tumor necrosis factor alpha (TNF-alpha). TIA-1 inhibits the translation of TNF-alpha transcripts, whereas TTP promotes the degradation of TNF-alpha transcripts. Here we show that TIA-1 and TTP function as arthritis suppressor genes: TIA-1(-/-) mice develop mild arthritis, TTP(-/-) mice develop severe arthritis, and TIA-1(-/-)TTP(-/-) mice develop very severe arthritis. Peritoneal macrophages derived from all three genotypes overexpress cyclooxygenase 2 and TNF-alpha. Surprisingly, lipopolysaccharide-activated TIA-1(-/-)TTP(-/-) macrophages secrete less TNF-alpha protein than either TIA-1(-/-) or TTP(-/-) macrophages. In these mice, arthritogenic cytokine may be produced by neutrophils that accumulate in the bone marrow and peripheral blood. Our results suggest that TIA-1 and TTP are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0400148101"xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/author | "Phillips K."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/author | "Blackshear P.J."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/author | "Anderson P."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/author | "Kedersha N."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/pages | "2011-2016"xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/title | "Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis."xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/14769925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14769925 |
| http://purl.uniprot.org/citations/14769925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14769925 |
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| http://purl.uniprot.org/uniprot/#_P22893-mappedCitation-14769925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14769925 |
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