| http://purl.uniprot.org/citations/14960283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14960283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14960283 | http://www.w3.org/2000/01/rdf-schema#comment | "The atypical PKCs (aPKCs) have been implicated genetically in at least two independent signaling cascades that control NF-kappa B and cell polarity, through the interaction with the adapters p62 and Par-6, respectively. P62 binds TRAF6, which plays an essential role in osteoclastogenesis and bone remodeling. Recently, p62 mutations have been shown to be the cause of the 5q35-linked Paget's disease of bone, a genetic disorder characterized by aberrant osteoclastic activity. Here we show that p62, like TRAF6, is upregulated during RANK-L-induced osteoclastogenesis and that the genetic inactivation of p62 in mice leads to impaired osteoclastogenesis in vitro and in vivo, as well as inhibition of IKK activation and NF-kappa B nuclear translocation. In addition, RANK-L stimulation leads to the inducible formation of a ternary complex involving TRAF6, p62, and the aPKCs. These observations demonstrate that p62 is an important mediator during osteoclastogenesis and induced bone remodeling."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(03)00403-9"xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(03)00403-9"xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Serrano M."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Serrano M."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Picard S."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Picard S."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Brown J.P."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Brown J.P."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Duran A."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Duran A."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Leitges M."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Leitges M."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Flores J.M."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/author | "Flores J.M."xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/14960283 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |