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| http://purl.uniprot.org/citations/14960318 | http://www.w3.org/2000/01/rdf-schema#comment | "We have evaluated the hypothesis that cGMP may serve as an intracellular messenger regulating the viability of pancreatic beta-cells. A direct activator of soluble guanylyl cyclase, YC-1, caused a time- and dose-dependent loss of viability in clonal BRIN-BD11 beta-cells. This was accompanied by a rise in cGMP and was antagonised by Rp-8-pCPT-cGMPS, a selective inhibitor of protein kinase G (PKG). Reverse transcription polymerase chain reaction analysis confirmed that BRIN-BD11 cells (and human islets) express all three known isoforms of PKG (PKG-Ialpha, -Ibeta and II). Cell death induced by YC-1 was not sensitive to cell-permeable caspase inhibitors and was not accompanied by oligonucleosomal DNA fragmentation. The response was, however, inhibited by actinomycin D, suggesting that a transcription-dependent pathway of programmed cell death is involved in the actions of cGMP."xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(04)00048-1"xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/author | "Kaminski A."xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/author | "Morgan N.G."xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/pages | "118-124"xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/title | "Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells."xsd:string |
| http://purl.uniprot.org/citations/14960318 | http://purl.uniprot.org/core/volume | "559"xsd:string |
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