| http://purl.uniprot.org/citations/14961764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14961764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14961764 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucling is a novel apoptosis-associated molecule, which is involved with cytochrome c /Apaf-1/caspase-9 apoptosome induction following pro-apoptotic stress. In the present study, we show first that Nucling is able to interact with galectin-3. Galectin-3 is known to participate in many biological processes, including apoptotic cell death. Nucling was found to down-regulate the expression level of galectin-3 mRNA/protein. Nucling-deficient cells, in which galectin-3 expression is up-regulated, appeared to be resistant to some forms of pro-apoptotic stress as compared with wild-type cells. In addition, the preputial gland from Nucling-deficient mice expressed a significant level of galectin-3 and exhibited a high incidence of inflammatory lesions, indicating that Nucling plays a crucial role in the homoeostasis of this gland by interacting with the galectin-3 molecule and regulating the expression level of galectin-3. Up-regulation of galectin-3 was also observed in the heart, kidney, lung, testis and ovary of the Nucling-deficient mice. In order to confirm the functional interaction between Nucling and galectin-3, a well-documented candidate for the mediator of galectin-3 expression, NF-kappaB (nuclear factor kappaB), was investigated as well. Nucling was shown to interfere with NF-kappaB activation via the nuclear translocation process of NF-kappaB/p65, thus inhibiting the expression of galectin-3. Taken together, we propose that Nucling mediates apoptosis by interacting and inhibiting expression of galectin-3."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20031300"xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20031300"xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Fukui K."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Fukui K."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Sano N."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/author | "Sano N."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/pages | "31-41"xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/pages | "31-41"xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/title | "Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/title | "Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling."xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/volume | "380"xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://purl.uniprot.org/core/volume | "380"xsd:string |
| http://purl.uniprot.org/citations/14961764 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14961764 |
| http://purl.uniprot.org/citations/14961764 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14961764 |