| http://purl.uniprot.org/citations/14963491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14963491 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila visual system has provided a model to study phototransduction and retinal degeneration. To identify new candidate proteins that contribute to these processes, we conducted a genome-wide screen for genes expressed predominately in the eye, using DNA microarrays. This screen appeared to be comprehensive as it led to the identification of all 22 eye-enriched genes previously shown to function in phototransduction or implicated in retinal degeneration. In addition, we identified 93 eye-enriched genes whose roles have not been previously defined. One of the eye-enriched genes encoded a member of a large family of transmembrane proteins, referred to as tetraspanins. We created a null mutation in the eye-enriched tetraspanin, Sunglasses (Sun), which resulted in light-induced retinal degeneration. We found that the Sun protein was distributed primarily in lysosomes, and functioned in a long-known but poorly understood phenomenon of light-induced degradation of rhodopsin. We propose that lysosomal tetraspanins in mammalian cells may also function in the downregulation of rhodopsin and other G-protein-coupled receptors, in response to intense or prolonged agonist stimulation."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600112"xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Li H.S."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Chodosh L.A."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Montell C."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Stoddard A."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/author | "Dugan K.D."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/pages | "811-822"xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/title | "A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen."xsd:string |
| http://purl.uniprot.org/citations/14963491 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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