| http://purl.uniprot.org/citations/14966521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14966521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14966521 | http://www.w3.org/2000/01/rdf-schema#comment | "Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit (the neurotrophin receptor p75). However, in reconstituted non-neuronal systems, NgR1 and p75 together are unable to activate RhoA, suggesting that additional components of the receptor may exist. Here we describe LINGO-1, a nervous system-specific transmembrane protein that binds NgR1 and p75 and that is an additional functional component of the NgR1/p75 signaling complex. In non-neuronal cells, coexpression of human NgR1, p75 and LINGO-1 conferred responsiveness to oligodendrocyte myelin glycoprotein, as measured by RhoA activation. A dominant-negative human LINGO-1 construct attenuated myelin inhibition in transfected primary neuronal cultures. This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1188"xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1188"xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Mi S."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Mi S."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Shao Z."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Shao Z."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "McCoy J.M."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "McCoy J.M."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Lee X."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Lee X."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Pepinsky R.B."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Pepinsky R.B."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Thill G."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Thill G."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Cate R.L."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Cate R.L."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Ji B."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Ji B."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Perrin S."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Perrin S."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Crowell T."xsd:string |
| http://purl.uniprot.org/citations/14966521 | http://purl.uniprot.org/core/author | "Crowell T."xsd:string |