http://purl.uniprot.org/citations/14967485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/14967485 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study aimed at characterizing the epitopes recognized by coxsackievirus B4 (CBV4)-specific T-cell lines established from 23 children with type 1 diabetes (T1D) and 29 healthy children with T1D risk-associated HLA genotypes. Responsiveness to VP1 region was dependent on the specific infection history as 55% of the T-cell lines from donors with neutralizing antibodies to CBV serotypes responded to VP1 peptides compared to none of the T-cell lines from other donors (P = 0.01). The pattern of recognized peptides was dependent of the HLA genotype. Forty-two percent of the T-cell lines from donors carrying the HLA-(DR4)-DQB1*0302 haplotype responded to VP1 peptides 71-80 compared to none of the T-cell lines from donors without this haplotype (P = 0.02). No evidence for the existence of diabetes-specific epitopes was found. Only few epitopes were exclusive recognized by T cells from diabetic children, and in each case only one or two T-cell lines were responding."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2003.10.011"xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/author | "Simell O."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/author | "Ilonen J."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/author | "Nanto-Salonen K."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/author | "Hyoty H."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/author | "Marttila J."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/pages | "27-35"xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/title | "Epitopes recognized by CBV4 responding T cells: effect of type 1 diabetes and associated HLA-DR-DQ haplotypes."xsd:string |
http://purl.uniprot.org/citations/14967485 | http://purl.uniprot.org/core/volume | "319"xsd:string |
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