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| http://purl.uniprot.org/citations/14967812 | http://www.w3.org/2000/01/rdf-schema#comment | "The effect of apolipoprotein A-II (apoA-II) on the structure and stability of HDL has been investigated in reconstituted HDL particles. Purified human apoA-II was incorporated into sonicated, spherical LpA-I particles containing apoA-I, phospholipids, and various amounts of triacylglycerol (TG), diacylglycerol (DG), and/or free cholesterol. Although the addition of PC to apoA-I reduces the thermodynamic stability (free energy of denaturation) of its alpha-helices, PC has the opposite effect on apoA-II and significantly increases its helical stability. Similarly, substitution of apoA-I with various amounts of apoA-II significantly increases the thermodynamic stability of the particle alpha-helical structure. ApoA-II also increases the size and net negative charge of the lipoprotein particles. ApoA-II directly affects apoA-I conformation and increases the immunoreactivity of epitopes in the N and C termini of apoA-I but decreases the exposure of central domains in the molecule (residues 98-186). ApoA-II appears to increase HL association with HDL and inhibits lipid hydrolysis. ApoA-II mildly inhibits PC hydrolysis in TG-enriched particles but significantly inhibits DG hydrolysis in DG-rich LpA-I. In addition, apoA-II enhances the ability of reconstituted LpA-I particles to inhibit VLDL-TG hydrolysis by HL. Therefore, apoA-II affects both the structure and the dynamic behavior of HDL particles and selectively modifies lipid metabolism."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300431-jlr200"xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/author | "Boucher J."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/author | "Sahoo D."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/author | "Braschi S."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/author | "Sparks D.L."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/author | "Ramsamy T.A."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/author | "Neville T.A."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/pages | "849-858"xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/title | "Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity."xsd:string |
| http://purl.uniprot.org/citations/14967812 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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