| http://purl.uniprot.org/citations/14969772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14969772 | http://www.w3.org/2000/01/rdf-schema#comment | "Ankylosing spondylitis (AS) is universally associated with human leukocyte antigen B27 (HLA-B27), although other genes could determine the development and clinical expression of the disease. HLA-A9 (A*2402) allele was previously found to be associated in Basque patients. The objective of this study is to perform a more precise analysis of microsatellite polymorphisms in HLA-A*2402 and B27 haplotypes to elucidate the significance of this association. A group of 50 unrelated AS patients and 113 controls of Basque origin were studied. Eight microsatellites in the class I major histocompatibility complex region with vicinity to HLA-A and -B were analyzed and the strength of allelic associations to AS and linkage disequilibrium (LD) between alleles were evaluated. Allele 15 at the microsatellite locus D6S248, 1000 Kb telomeric to HLA-A showed a strong positive association with the disease (OR:6; pc=4.7x10(-4)) and it could not be explained by LD to HLA-B27, HLA-A*2402 or any other loci. We found that D6S248-15 allele together with HLA-A*2402 could be B27-independent markers of additional susceptibility gene/s localised in the region telomeric to HLA-A in Basque AS patients."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2003.11.006"xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/author | "Figueroa M."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/author | "de Juan M.D."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/author | "Cuadrado E."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/author | "Reta A."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/author | "Belzunegui J."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/author | "Maruri N."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/pages | "175-180"xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/title | "HLA-A*2402 and a microsatellite (D6S248) are secondary independent susceptibility markers to ankylosing spondylitis in Basque patients."xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/14969772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14969772 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-14969772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14969772 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-14969772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14969772 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-14969772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14969772 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-14969772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14969772 |
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