| http://purl.uniprot.org/citations/14970201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14970201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14970201 | http://www.w3.org/2000/01/rdf-schema#comment | "GEF-H1 is a guanine nucleotide exchange factor for Rho whose activity is regulated through a cycle of microtubule binding and release. Here we identify a region in the carboxyl terminus of GEF-H1 that is important for suppression of its guanine nucleotide exchange activity by microtubules. This portion of the protein includes a coiled-coil motif, a proline-rich motif that may interact with Src homology 3 domain-containing proteins, and a potential binding site for 14-3-3 proteins. We identify GEF-H1 as a binding target and substrate for p21-activated kinase 1 (PAK1), an effector of Rac and Cdc42 GTPases, using an affinity-based screen and localize a PAK1 phosphorylation site to the inhibitory carboxyl-terminal region of GEF-H1. We show that phosphorylation of GEF-H1 at Ser(885) by PAK1 induces 14-3-3 binding to the exchange factor and relocation of 14-3-3 to microtubules. Phosphorylation of GEF-H1 by PAK may be involved in regulation of GEF-H1 activity and may serve to coordinate Rho-, Rac-, and Cdc42-mediated signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m400084200"xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m400084200"xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Bohl B.P."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Bohl B.P."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Bokoch G.M."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Bokoch G.M."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "DerMardirossian C."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "DerMardirossian C."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "King C.C."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "King C.C."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Krendel M."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Krendel M."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Zenke F.T."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/author | "Zenke F.T."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/pages | "18392-18400"xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/pages | "18392-18400"xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/title | "p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor."xsd:string |
| http://purl.uniprot.org/citations/14970201 | http://purl.uniprot.org/core/title | "p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor."xsd:string |