| http://purl.uniprot.org/citations/14970264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14970264 | http://www.w3.org/2000/01/rdf-schema#comment | "The basic helix-loop-helix tal-1 gene (or scl), known for its fundamental role in embryonic and adult hematopoiesis in vertebrates, is also required for embryonic vascular remodeling. In adults, TAL-1 protein is undetectable in quiescent endothelium but it is present in newly formed vessels including tumoral vasculature, indicating its involvement in angiogenesis. Here, we demonstrate that TAL-1 expression is tightly regulated during in vitro angiogenesis: it is low during the initial step of migration and is upregulated during formation of capillary-like structures. We investigated whether ectopic expression of either wild-type TAL-1 or a dominant-negative mutant lacking the DNA-binding domain (Delta-bas) modulates the activity of human primary endothelial cells in the angiogenic processes of migration, proliferation and cell morphogenesis. Overexpression of either wild-type or Delta-bas TAL-1 affected chemotactic migration of primary endothelial cells without modifying their proliferative properties. Ectopic expression of wild-type TAL-1 accelerated the formation of capillary-like structures in vitro and, in vivo, enhanced vascularisation in mice (Matrigel implants) associated with a general enlargement of capillary lumens. Importantly, transduction of the mutant Delta-bas completely impaired in vitro angiogenesis and strongly inhibited vascularisation in mice. Taken together, our data show that TAL-1 modulates the angiogenic response of endothelial cells by stimulating cell morphogenesis and by influencing their behavior in migration. This study highlights the importance of TAL-1 regulation in postnatal vascular remodeling and provides the first physiological evidence that links TAL-1 activity to endothelial cell morphogenic processes."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.00969"xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Noel D."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Mathieu D."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Robbins I."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Dohet C."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Chalhoub E."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Deleuze V."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Haouzi D."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/author | "Lazrak M."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/pages | "1161-1171"xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/title | "The bHLH TAL-1/SCL regulates endothelial cell migration and morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/14970264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14970264 |
| http://purl.uniprot.org/citations/14970264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14970264 |
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| http://purl.uniprot.org/uniprot/#_P17542-mappedCitation-14970264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14970264 |
| http://purl.uniprot.org/uniprot/#_Q9NY94-mappedCitation-14970264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14970264 |
| http://purl.uniprot.org/uniprot/#_Q9UE36-mappedCitation-14970264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14970264 |
| http://purl.uniprot.org/uniprot/P17542 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14970264 |
| http://purl.uniprot.org/uniprot/Q9UE36 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14970264 |
| http://purl.uniprot.org/uniprot/Q16509 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14970264 |