| http://purl.uniprot.org/citations/14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14973280 | http://www.w3.org/2000/01/rdf-schema#comment | "In the Drosophila CNS, neuroblasts undergo self-renewing asymmetric divisions, whereas their progeny, ganglion mother cells (GMCs), divide asymmetrically to generate terminal postmitotic neurons. It is not known whether GMCs have the potential to undergo self-renewing asymmetric divisions. It is also not known how precursor cells undergo self-renewing asymmetric divisions. Here, we report that maintaining high levels of Mitimere or Nubbin, two POU proteins, in a GMC causes it to undergo self-renewing asymmetric divisions. These asymmetric divisions are due to upregulation of Cyclin E in late GMC and its unequal distribution between two daughter cells. GMCs in an embryo overexpressing Cyclin E, or in an embryo mutant for archipelago, also undergo self-renewing asymmetric divisions. Although the GMC self-renewal is independent of inscuteable and numb, the fate of the differentiating daughter is inscuteable and numb-dependent. Our results reveal that regulation of Cyclin E levels, and asymmetric distribution of Cyclin E and other determinants, confer self-renewing asymmetric division potential to precursor cells, and thus define a pathway that regulates such divisions. These results add to our understanding of maintenance and loss of pluripotential stem cell identity."xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01014"xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/author | "Bhat K.M."xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/author | "Apsel N."xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/pages | "1123-1134"xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/title | "Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cells."xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/14973280 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14973280 |
| http://purl.uniprot.org/citations/14973280 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14973280 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6Q6-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K630-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_A8DYZ8-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_A4V0R4-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_M9PCN6-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_P22808-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_P28166-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_P16554-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_H0RNL2-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_Q24367-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_M9NDQ2-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_P06602-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |
| http://purl.uniprot.org/uniprot/#_P02835-mappedCitation-14973280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14973280 |