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http://purl.uniprot.org/citations/14977834http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14977834http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The aim of this study was to evaluate the prevalence and the clinical significance of HIN-1 mRNA expression in early stage non-small cell lung carcinomas (NSCLCs).

Experimental design

A series of 91 NSCLC patients with stage I neoplastic disease was studied. HIN-1 expression was investigated by quantitative real-time reverse transcription-PCR on tumor specimens and matching normal lung tissues. Variables were analyzed by chi(2) test and Fisher's exact tests. Survival was evaluated with the method of Kaplan-Meier. Multivariate analysis was performed with Cox's proportional hazards model.

Results

Seventy one (78%) tumors showed a reduction of HIN-1 mRNA compared with the normal counterpart. The range of reduction varied greatly, from -2-fold to -3350-fold. Setting a cutoff at -46-fold (median value of HIN-1 mRNA reduction), 46 cases (51%) had a markedly reduced expression, and 45 cases (49%) showed a normal or slightly reduced expression. A statistically significant association between low HIN-1 mRNA levels and T status was observed (P = 0.036). Univariate survival curves, estimated using the method of Kaplan-Meier, defined a significant association between HIN-1 expression and both overall survival (P = 0.0095) and disease-free survival (P = 0.0122). A multivariate analysis, performed by Cox's proportional hazards regression model, confirmed that a low HIN-1 expression was the only significant factor to predict poor prognosis.

Conclusions

Our data indicate that HIN-1 expression, measured by real-time reverse transcription-PCR, is a possible prognostic factor in patients with stage I NSCLC. Additional studies are required to further validate this potential prognostic marker."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.org/dc/terms/identifier"doi:10.1158/1078-0432.ccr-1174-03"xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Marchetti A."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Martella C."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Sacco R."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Buttitta F."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Barassi F."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Chella A."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Mucilli F."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Salvatore S."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/author"Castrataro A."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/name"Clin Cancer Res"xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/pages"1338-1343"xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/title"Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome."xsd:string
http://purl.uniprot.org/citations/14977834http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/14977834http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14977834
http://purl.uniprot.org/citations/14977834http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14977834
http://purl.uniprot.org/uniprot/#_Q96QR1-mappedCitation-14977834http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14977834
http://purl.uniprot.org/uniprot/Q96QR1http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/14977834