| http://purl.uniprot.org/citations/14977952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14977952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14977952 | http://www.w3.org/2000/01/rdf-schema#comment | "Antimicrobial peptides are secreted by small intestinal Paneth cells as components of innate immunity. To investigate the role of alpha-defensins in enteric host defenses in nonhuman primates, alpha-defensin cDNAs were isolated, alpha-defensin peptides were purified from rhesus macaque small bowel, and the bactericidal activities of the peptides were measured. Six rhesus enteric alpha-defensin (RED) cDNAs, RED-1 to RED-6, were identified in a jejunum cDNA library; the deduced RED peptides exhibited extensive diversity relative to the primary structures of rhesus myeloid alpha-defensins. RED-4 was purified from monkey jejunum, and N-terminal peptide sequencing of putative RED-4 peptides identified two N termini, RTCYCRTGR. and TCYCRTGRC.; these corresponded to alternative N termini for the RED-4 molecules, as deduced from their molecular masses and RED cDNAs. In situ hybridization experiments localized RED mRNAs exclusively to small intestinal Paneth cells. Recombinant RED-1 to RED-4 were purified to homogeneity and shown to be microbicidal in the low micromolar range (xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.org/dc/terms/identifier | "doi:10.1128/IAI.72.3.1470-1478.2004"xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.72.3.1470-1478.2004"xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Tanabe H."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Tanabe H."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Dandekar S."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Dandekar S."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Henschen-Edman A."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Henschen-Edman A."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Selsted M.E."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Selsted M.E."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Ouellette A.J."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Ouellette A.J."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Zaragoza M.M."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/author | "Zaragoza M.M."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/name | "Infect. Immun."xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/pages | "1470-1478"xsd:string |
| http://purl.uniprot.org/citations/14977952 | http://purl.uniprot.org/core/pages | "1470-1478"xsd:string |