| http://purl.uniprot.org/citations/14978215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14978215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14978215 | http://www.w3.org/2000/01/rdf-schema#comment | "Caveolae are a subset of lipid rafts enriched in glycosphingolipids and cholesterol-rich domains, but selectively lacking glycosylphosphatidyl inositol-anchored proteins (GPI-APs). Caveolin proteins are the organizing component of caveolae, but the corresponding proteins for other classes of lipid rafts are poorly defined. Epithelial membrane protein-2 (EMP2), a member of the four-transmembrane superfamily, facilitates plasma membrane delivery of certain integrins. In this study, we found by laser confocal microscopy that EMP2 was associated with GPI-APs (detected by the GPI-AP binding bacterial toxin proaerolysin). Biochemical membrane fractionation and methyl-beta-cyclodextrin treatment demonstrated that this association occurred within lipid rafts. EMP2 did not associate with caveolin-bearing membrane structures, and recombinant overexpression of EMP2 in NIH3T3 cells decreased caveolin-1 and caveolin-2 protein levels while increasing the surface expression of GPI-APs. Conversely, a ribozyme construct that specifically cleaves the EMP2 transcript reduced surface GPI-APs and increased caveolin protein expression. These findings suggest that EMP2 facilitates the formation and surface trafficking of lipid rafts bearing GPI-APs, and reduces caveolin expression, resulting in impaired formation of caveolae."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-07-0488"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-07-0488"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/author | "Braun J."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/author | "Braun J."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/author | "Goodglick L."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/author | "Goodglick L."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/author | "Wadehra M."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/author | "Wadehra M."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/pages | "2073-2083"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/pages | "2073-2083"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/title | "The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/title | "The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins."xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/14978215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14978215 |
| http://purl.uniprot.org/citations/14978215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14978215 |
| http://purl.uniprot.org/citations/14978215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14978215 |
| http://purl.uniprot.org/citations/14978215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14978215 |