| http://purl.uniprot.org/citations/14980219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14980219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14980219 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms that control the precisely regulated switch from gene repression to gene activation represent a central question in mammalian development. Here, we report that transcriptional activation mediated by liganded nuclear receptors unexpectedly requires the actions of two highly related F box/WD-40-containing factors, TBL1 and TBLR1, initially identified as components of an N-CoR corepressor complex. TBL1/TBLR1 serve as specific adaptors for the recruitment of the ubiquitin conjugating/19S proteasome complex, with TBLR1 selectively serving to mediate a required exchange of the nuclear receptor corepressors, N-CoR and SMRT, for coactivators upon ligand binding. Tbl1 gene deletion in embryonic stem cells severely impairs PPARgamma-induced adipogenic differentiation, indicating that TBL1 function is also biologically indispensable for specific nuclear receptor-mediated gene activation events. The role of TBLR1 and TBL1 in cofactor exchange appears to also operate for c-Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal-dependent transcription factors."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(04)00133-3"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(04)00133-3"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Aggarwal A."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Aggarwal A."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Rose D.W."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Perissi V."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/author | "Perissi V."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/pages | "511-526"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/pages | "511-526"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/title | "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/title | "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors."xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/14980219 | http://purl.uniprot.org/core/volume | "116"xsd:string |