| http://purl.uniprot.org/citations/14982859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14982859 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic defects in the plasma membrane-associated sarcoglycan complex produce cardiomyopathy characterized by focal degeneration. The infarct-like pattern of cardiac degeneration has led to the hypothesis that coronary artery vasospasm underlies cardiomyopathy in this disorder. We evaluated the coronary vasculature of gamma-sarcoglycan mutant mice and found microvascular filling defects consistent with arterial vasospasm. However, the vascular smooth muscle sarcoglycan complex was intact in the coronary arteries of gamma-sarcoglycan hearts with perturbation of the sarcoglycan complex only within the adjacent myocytes. Thus, in this model, coronary artery vasospasm derives from a vascular smooth muscle-cell extrinsic process. To reduce this secondary vasospasm, we treated gamma-sarcoglycan-deficient mice with the calcium channel antagonist verapamil. Verapamil treatment eliminated evidence of vasospasm and ameliorated histological and functional evidence of cardiomyopathic progression. Echocardiography of verapamil-treated, gamma-sarcoglycan-null mice showed an improvement in left ventricular fractional shortening (44.3 +/-13.3% treated versus 37.4 +/-15.3% untreated), maximal velocity at the aortic outflow tract (114.9 +/-27.9 cm/second versus 92.8 +/- 22.7 cm/second), and cardiac index (1.06 +/-0.30 ml/minute/g versus 0.67 +/-0.16 ml/minute/g, P < 0.05). These data indicate that secondary vasospasm contributes to the development of cardiomyopathy and is an important therapeutic target to limit cardiomyopathy progression."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)63193-8"xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Hack A.A."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Collins K.A."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Wheeler M.T."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Lyons M.R."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "McNally E.M."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Earley J.U."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Zarnegar S."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Korcarz C.E."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Lang R.M."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/author | "Lapidos K.A."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/pages | "1063-1071"xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/title | "Secondary coronary artery vasospasm promotes cardiomyopathy progression."xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://purl.uniprot.org/core/volume | "164"xsd:string |
| http://purl.uniprot.org/citations/14982859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14982859 |
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