| http://purl.uniprot.org/citations/14982883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14982883 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF1 tumor suppressor gene encodes a guanosine triphosphotase (GTPase)-activating protein that negatively regulates Ras signaling and is inactivated in a subset of juvenile myelomonocytic leukemias (JMMLs). Adoptive transfer of fetal liver cells from Nf1 mutant mice models JMML; however, this system has important limitations as a platform for performing biologic and preclinical studies. We have exploited the interferon-inducible Mx1-Cre transgene to ablate a conditional mutant Nf1 allele in hematopoietic cells. Somatic inactivation of Nf1 induces a myeloproliferative disorder with 100% penetrance that is associated with a sub-acute clinical course, tissue infiltration by myeloid cells, hypersensitivity to granulocyte-macrophage colony stimulating factor, hyperproliferation, and resistance to apoptosis. These Mx1-Cre, Nf1(flox/flox) mice establish a tractable experimental model for testing therapeutics and for identifying mutations that cooperate with hyperactive Ras in myeloid leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-08-2650"xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Wang E."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Le Beau M.M."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Le D.T."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Kogan S.C."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Shannon K.M."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Braun B.S."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Lauchle J.O."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Kong N."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Aiyigari A."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/author | "Parada L."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/pages | "4243-4250"xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/title | "Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder."xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/14982883 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14982883 |
| http://purl.uniprot.org/citations/14982883 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14982883 |
| http://purl.uniprot.org/uniprot/Q04690#attribution-F4E482CB20CCD66D5260AFAD1FE63D62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14982883 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P863-mappedCitation-14982883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14982883 |
| http://purl.uniprot.org/uniprot/#_Q3TYD2-mappedCitation-14982883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14982883 |
| http://purl.uniprot.org/uniprot/#_Q04690-mappedCitation-14982883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14982883 |