| http://purl.uniprot.org/citations/14985359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14985359 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytoplasmic dynein and kinesin I are both unidirectional intracellular motors. Dynein moves cargo toward the cell center, and kinesin moves cargo toward the cell periphery. There is growing evidence that bi-directional motility is regulated in the cell, potentially through direct interactions between oppositely oriented motors. We have identified a direct interaction between cytoplasmic dynein and kinesin I. Using the yeast two-hybrid assay and affinity chromatography, we demonstrate that the intermediate chain of dynein binds to kinesin light chains 1 and 2. The interaction is both direct and specific. Co-immunoprecipitation experiments demonstrate an interaction between endogenous proteins in rat brain cytosol. Double-label immunocytochemistry reveals a partial co-localization of vesicle-associated motor proteins. Together these observations suggest that soluble motors can interact, potentially allowing kinesin I to actively localize dynein to cellular sites of function. There is also a vesicle population with both dynein and kinesin I bound that may be capable of bi-directional motility along cellular microtubules."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313472200"xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/author | "Holzbaur E.L."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/author | "Ligon L.A."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/author | "Tokito M."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/author | "Finklestein J.M."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/author | "Grossman F.E."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/pages | "19201-19208"xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/title | "A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity."xsd:string |
| http://purl.uniprot.org/citations/14985359 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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