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http://purl.uniprot.org/citations/14990915http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14990915http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The aim of the study was to determine whether susceptibility or resistance to Artemisia pollen-induced allergic rhinitis was associated with HLA class II DQA1, DQB1 loci. Study design and setting Forty-one subjects with allergic rhinitis and 41 healthy controls from Beijing were genotyped at HLA class II DQA1, DQB1 alleles by polymerase chain reaction amplification with sequence-specific primers-based technique.

Results

The allele frequencies of HLA-DQA1*0201, DQB1*0602 were lower in patients with allergic rhinitis compared with the controls (24.39% versus 46.34%, P = 0.038; 4.88% versus 26.83%, P = 0.007), and the frequency of DQA1*0302 was higher among patients than the controls (58.54% versus 14.63%, P = 0.00004, Pc = 0.0004).

Conclusion and significance

HLA-DQA1 and -DQB1 genes may be involved in the development of Artemisia pollen-induced allergic rhinitis. HLA-DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen-induced allergic rhinitis."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.org/dc/terms/identifier"doi:10.1016/j.otohns.2003.08.012"xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/author"Wang M."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/author"Yan Z."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/author"Yu D.L."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/author"Yu L.S."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/author"Xing Z.M."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/name"Otolaryngol Head Neck Surg"xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/pages"192-196"xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/title"Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population."xsd:string
http://purl.uniprot.org/citations/14990915http://purl.uniprot.org/core/volume"130"xsd:string
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