| http://purl.uniprot.org/citations/14991457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14991457 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the quantity and quality of G proteins in membrane preparations of post-mortem human brain, i.e. in parietal, temporal and occipital cortical regions, from normal subjects over age (17-89 years old) and with Alzheimer's disease (AD) in comparison with aged-matched controls. In normal aging, the immunoreactivities determined of G(ialpha), G(qalpha) and G(beta) were inversely correlated with age. The function of G proteins was examined by photoaffinity GTP analogue [azidoanilido GTP (AAGTP)] labelling. AAGTP labelling to G(salpha) and G(i/oalpha), and the ratio of G(salpha) to G(i/oalpha) AAGTP labelling showed no age-dependent changes. In AD compared to age-matched controls, there were no significant differences in the levels of G(sHalpha), G(sLalpha), G(ialpha), G(oalpha), G(qalpha) and G(beta) subunits. Functional effects of G proteins, however, as measured by AAGTP labelling to G(salpha), but not to G(i/oalpha), was significantly decreased in AD compared to controls in the parietal and temporal cortex, but not in the occipital cortex. These results suggest that the disturbances of post-receptor trans-membrane signalling in AD can be attributed to functional changes of G(salpha), and these are independent of alterations in the level for those proteins in normal aging."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00702-003-0089-4"xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Takahata N."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Ozawa H."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Hashimoto E."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Riederer P."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Frolich L."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/author | "Gsell W."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/name | "J Neural Transm (Vienna)"xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/pages | "311-322"xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/title | "Impairment of G(salpha) function in human brain cortex of Alzheimer's disease: comparison with normal aging."xsd:string |
| http://purl.uniprot.org/citations/14991457 | http://purl.uniprot.org/core/volume | "111"xsd:string |
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