| http://purl.uniprot.org/citations/14993273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14993273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14993273 | http://www.w3.org/2000/01/rdf-schema#comment | "Dok-3 is a Dok-related adaptor expressed in B cells and macrophages. Previously, we reported that Dok-3 is an inhibitor of B-cell activation in A20 B cells and that it associates with SHIP-1, a 5' inositol-specific lipid phosphatase, as well as Csk, a negative regulator of Src kinases. Here, we demonstrate that Dok-3 suppresses B-cell activation by way of its interaction with SHIP-1, rather than Csk. Our biochemical analyses showed that the Dok-3-SHIP-1 complex acts by selectively inhibiting the B-cell receptor (BCR)-evoked activation of the Jun N-terminal protein kinase (JNK) cascade without affecting overall protein tyrosine phosphorylation or activation of previously described SHIP-1 targets like Btk and Akt/PKB. Studies of B cells derived from SHIP-1-deficient mice showed that BCR-triggered activation of JNK is enhanced in the absence of SHIP-1, implying that the Dok-3-SHIP-1 complex (or a related mechanism) is a physiological negative regulator of the JNK cascade in normal B cells. Together, these data elucidate the mechanism by which Dok-3 inhibits B-cell activation. Furthermore, they provide evidence that SHIP-1 can be a negative regulator of JNK signaling in B cells."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.6.2332-2343.2004"xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.6.2332-2343.2004"xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/author | "Robson J.D."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/author | "Robson J.D."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/pages | "2332-2343"xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/pages | "2332-2343"xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/title | "Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/title | "Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3."xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14993273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14993273 |
| http://purl.uniprot.org/citations/14993273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14993273 |
| http://purl.uniprot.org/citations/14993273 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14993273 |
| http://purl.uniprot.org/citations/14993273 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14993273 |