| http://purl.uniprot.org/citations/14993594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14993594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14993594 | http://www.w3.org/2000/01/rdf-schema#comment | "Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen. Type I IFN production can be induced both by unmethylated CpG-oligodeoxynucleotide and by double-stranded RNA. Here, we describe a codominant CpG-ODN unresponsive phenotype that results from an N-ethyl-N-nitrosourea-induced missense mutation in the Tlr9 gene (Tlr9(CpG1)). Mice homozygous for the Tlr9(CpG1) allele are highly susceptible to mouse cytomegalovirus infection and show impaired infection-induced secretion of IFN-alpha/beta and natural killer cell activation. We also demonstrate that both the Toll-like receptor (TLR) 9 --> MyD88 and TLR3 --> Trif signaling pathways are activated in vivo on viral inoculation, and that each pathway contributes to innate defense against systemic viral infection. Whereas both pathways lead to type I IFN production, neither pathway offers full protection against mouse cytomegalovirus infection in the absence of the other. The Tlr9(CpG1) mutation alters a leucine-rich repeat motif and lies within a receptor domain that is conserved within the evolutionary cluster encompassing TLRs 7, 8, and 9. In other TLRs, including three mouse-specific TLRs described in this paper, the affected region is not represented. The phenotypic effect of the Tlr9(CpG1) allele thus points to a critical role for TLR9 in viral sensing and identifies a vulnerable amino acid within the ectodomain of three TLR proteins, essential for a ligand response."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0400525101"xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0400525101"xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Beutler B."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Beutler B."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Alexopoulou L."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Alexopoulou L."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Janssen E."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Janssen E."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Georgel P."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Georgel P."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Mudd S."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Mudd S."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Shamel L."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Shamel L."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Sovath S."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Sovath S."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Crozat K."xsd:string |
| http://purl.uniprot.org/citations/14993594 | http://purl.uniprot.org/core/author | "Crozat K."xsd:string |