| http://purl.uniprot.org/citations/14993672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14993672 | http://www.w3.org/2000/01/rdf-schema#comment | "Piperidine ligands are described that provide the first examples of non-peptidic ligand structures for the cyclophilin family of proteins. Crystal structures of two ligand complexes are compared with the unliganded protein and show ligand-induced changes in side-chain conformation and water binding. A peptidylprolyl cis-trans-isomerase assay showed the dissociation constants of the two ligands to be 320 and 25 mM. This study also provides the first published data for both enzymatic activity and three-dimensional structure for any protein-ligand complex that binds with a high-millimolar dissociation constant. The structures may be of relevance in the field of drug design, as they suggest starting points for the design of larger tighter-binding analogues."xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444904000174"xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/author | "Taylor P."xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/author | "Walkinshaw M.D."xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/author | "Kontopidis G."xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/name | "Acta Crystallogr D Biol Crystallogr"xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/pages | "479-485"xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/title | "Enzymatic and structural characterization of non-peptide ligand-cyclophilin complexes."xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/14993672 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14993672 |
| http://purl.uniprot.org/citations/14993672 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14993672 |
| http://purl.uniprot.org/uniprot/P62937#attribution-09ABFCB22A4E65A8DABAAB3520B95432 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14993672 |
| http://purl.uniprot.org/uniprot/#_P62937-mappedCitation-14993672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14993672 |
| http://purl.uniprot.org/uniprot/P62937 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14993672 |